LAUSR

Objectives The present study examined the abnormal resting state functional connections (RSFCs) in structural deficit brain regions of primary insomnia (PI) patients. Methods Thirty-three PI patients and 38 well-matched healthy controls participated in our study. We used voxel-based morphometry and RSFC to study functional connectivity abnormalities of brain regions with structural deficits in PI patients. Results PI patients showed decreased gray matter (GM) volume in the left dorsolateral prefrontal cortex, left orbitofrontal cortex (OFC), bilateral middle frontal gyrus (MFC), right inferior frontal gyrus (IFG), and left inferior temporal gyrus. Gray matter volume in the right MFC negatively correlated with Self-Rating Scale of Sleep (SRSS) scores, and GM volume in the right IFG negatively correlated with SRSS and Insomnia Severity Index (ISI) scores. Therefore, the right MFC and right IFG were selected as regions of interest for RSFC analysis. PI patients had weakened RSFC between the right inferior parietal gyrus (IPC) and the right MFC compared to the healthy controls and between the left OFC and right IFG. The RSFC between the right MFC and right IPC negatively correlated with SRSS scores. The RSFC between the right IFG and left OFC negatively correlated with SRSS, ISI, SAS, and SDS scores. Conclusions The present study found structural changes in the right MFC and right IFG accompanied by RSFC changes. This finding may provide novel insights into the neural mechanisms of PI via combining structural and functional modality information.