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The article Expression and Prognostic Role of Glia Maturation Factor- γ in Gliomas by Liu et al. investigated the role of glia maturation factor- γ (GMFG) in gliomas. Public datasets… Click to show full abstract
The article Expression and Prognostic Role of Glia Maturation Factor- γ in Gliomas by Liu et al. investigated the role of glia maturation factor- γ (GMFG) in gliomas. Public datasets comprising 2,518 gliomas samples and an in-house cohort containing 120 gliomas samples were evaluated. Bioinformatic tools were used to assess the correlation between GMFG expression and immune cell infiltration and to determine the prognostic role of GMFG and its association with temozolomide (TMZ) response in gliomas. GMFG expression was found higher in gliomas and was associated with a bad response to TMZ treatment. This work supports GMFG as a prognostic biomarker for low-grade glioma and glioblastoma multiforme and describes important progress in the development of advanced therapies for gliomas.
Journal Title: Frontiers in Molecular Neuroscience
Year Published: 2023
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