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Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein… Click to show full abstract
Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for the treatment of upfront AML in an unfit, elderly population. This paper reviews the pre-clinical and clinical data for apoptosis inhibitors currently in development for the treatment of AML, ALL, and MDS.
Keywords:
apoptosis acute;
acute leukemias;
role inhibition;
myelodysplastic syndrome;
leukemias myelodysplastic;
inhibition apoptosis
Journal Title: Frontiers in Oncology
Year Published: 2019
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Journal Title: Frontiers in Oncology
Year Published: 2019
Link to full text (if available)
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recommendations!