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Targeting CD47 as a Novel Immunotherapy for Breast Cancer

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Nowadays, breast cancer has become the most common cancer worldwide with a high mortality rate. Immune checkpoint blockade holds great promise in tumor‐targeted therapy, and CD47 blockade as one immune… Click to show full abstract

Nowadays, breast cancer has become the most common cancer worldwide with a high mortality rate. Immune checkpoint blockade holds great promise in tumor‐targeted therapy, and CD47 blockade as one immune therapy is undergoing various preclinical studies and clinical trials to demonstrate its safety and efficacy in breast cancer. In this review, we summarized different therapeutic mechanisms targeting CD47 and its prognostic role and therapeutic value in breast cancer.

Keywords: cd47 novel; targeting cd47; breast cancer; novel immunotherapy; cancer

Journal Title: Frontiers in Oncology
Year Published: 2022

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