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The therapeutic benefits of many stem cell-based therapies are now widely believed to be mediated through the secretion of paracrine factors, such as cytokines, chemokines, growth factors, and extracellular vesicles… Click to show full abstract
The therapeutic benefits of many stem cell-based therapies are now widely believed to be mediated through the secretion of paracrine factors, such as cytokines, chemokines, growth factors, and extracellular vesicles (EVs). The future of stem cell-based therapies may well lie in our ability to manipulate these factors. As stem cells are sensitive to their microenvironment, the components of their secretome may be manipulated by altering their culture conditions. This themed issue comprises narrative reviews and original research articles on the emerging therapeutic use of stem cells and EVs, along with novel bioengineering and manufacturing technologies that leverage these paracrine outputs.
Journal Title: Frontiers in Pharmacology
Year Published: 2020
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