A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones… Click to show full abstract
A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under structured illumination microscopy, compound 3a is found to change the mitochondrial morphology and induce mitophagy pathway, which might then trigger mitophagy in cancer cells.
Keywords:
spirobi indolin;
synthesis spirobi;
ones preliminary;
efficient synthesis;
indolin ones
Journal Title: Frontiers in Pharmacology
Year Published: 2021
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Journal Title: Frontiers in Pharmacology
Year Published: 2021
Link to full text (if available)
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recommendations!