LAUSR

Meniscus is a kind of fibrocartilage composite tissue which plays an important role in the stability, load distribution and shock absorption of the knee joint. In addition, meniscus can absorb the impact and provide nutrition. Meniscus is mainly composed of water, collagen, glycosaminoglycan, etc. Meniscal injury is one of the most common sports injuries. After meniscal injury, traditional repair, suture or meniscectomy are currently used for clinical treatment. However, due to the limited number of blood vessels, it is difficult to heal, and may even lead to knee arthritis and osteoarthritis. Therefore, the field of meniscal in which alternative regenerativemedicine is being studied has attracted attention, especially stem cells as the best source of cells to help stimulate the regeneration of natural tissues of meniscal. although only limited relevant research has been conducted at present, mesenchymal stem cells are a very good idea for repairing human joint meniscus injury (Prabhath et al., 2021). Stem cells have been studied by more and more experts and scholars due to their unique characteristics, such as self-renewal, proliferation and differentiation, immune regulation and plasticity. However, these cells are limited in their clinical application due to their tumorigenesis. However, among the various stem cell types, mesenchymal stem cells (MSCs) have a lower risk of formation due to the teratoma they carry (Huldani et al., 2022)Without any ethical issues, and its readily available sources, have been the subject of most therapeutic application studies. Studies have isolated, cultured and amplified bone marrow mesenchymal stem cells from animals such as sheep and used them in various transformation models for human medical applications (Gugjoo and Amarpal, 2018). There are also many studies that have evaluated MSCs including cartilage, tendon and construct (Gugjoo et al., 2020). The research summarizes the repair methods of meniscal injury, especially the application of mesenchymal stem cells in the meniscal injury of joint. Many researchers have used a variety of methods to treat meniscal injury with stem cells in animal experiments, to promote the healing of meniscal. Although some results have been achieved, it cannot be widely used in human body, and it is hoped that it can be applied to clinical practice in the near future.