LAUSR

In our opinion, cardiovascular proteomics is the most perspective field of proteomic research in space and Earth medicine. Proteomics, being still a relatively new discipline of fundamental research, is becoming not only a methodology for screening potential biomarkers in various cells, tissues, and biological fluids but also a method for determining the targets of therapeutic agents (Huang et al., 2017). Widely, understanding how multiple protein species interact to carry out regulation is an important objective of cardiovascular research. Besides, the power of proteomics to simultaneously provide information on the panoply of expressed proteins has made it uniquely suitable for resolving complex signaling conundrums and revealing cardiovascular diseases (CVD). (Lam et al., 2016). When using proteomic analysis in the cardiovascular system (CVS), two main strategies are relevant (Mokou et al., 2017): obtaining information about molecular physiological mechanisms and identification of biomarkers that reflect the dynamics of adaptation processes. The variety of CVS adaptive responses is ensured by the high variability of the metabolic circuit of regulation of this system since numerous molecular mechanisms are involved in this process and, first of all, in the regulation of heart rate. From a physiological point of view, heart rate variability (HRV) is an integral characteristic that reflects not only the adaptive response of the CVS (Thayer and Lane, 2007; Thayer et al., 2010; Ernst, 2017) but also of more complex neural networks (Thayer et al., 2012). However, the relationships between HRV and metabolic parameters under conditions of space flight (SF) conditions and clinical studies are poorly understood.