Identifying causes of death, let alone COVID-19-specific mortality, is a challenge in many lowand middle-income countries. Lack of testing and large numbers of community deaths without a physician to medically… Click to show full abstract
Identifying causes of death, let alone COVID-19-specific mortality, is a challenge in many lowand middle-income countries. Lack of testing and large numbers of community deaths without a physician to medically certify the cause of death, are barriers to knowing the full impact of the pandemic on mortality [1]. Verbal Autopsy (VA) is a technique for determining the most medically likely causes of death in the community, where no physician is available to complete a medical certificate of cause of death. Briefly, VA uses a structured questionnaire to elicit the signs and symptoms exhibited by the deceased in the period before death and that can reliably be understood by and reported on by family members and other lay caregivers [2]. The pattern of responses to the VA questionnaire is used by physicians or a computer algorithm to assign the most probable cause of death [3, 4]. As part of the development of the Rapid Mortality Surveillance Technical Package, the WHO VA Reference Group produced a short questionnaire and algorithm, the InterVA CRMS model [5], to distinguish deaths due to COVID-like illness (CLI) from deaths due to other natural and unnatural causes. The algorithm produces estimates of the probability of death being associated with CLI, based on the answers in the short questionnaire. This study aims to evaluate the performance of the InterVA CRMS model against ultrasound guided-minimally invasive autopsy, which is the best available reference during the pandemic. To our knowledge, no study with this purpose has been carried out yet.
               
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