LAUSR

A Forum discussing: Development of Ex Situ Normothermic Reperfusion as an Innovative Method to Assess Pancreases After Preservation We read with great interest the paper entitled “ Development of Ex Situ Normothermic Reperfusion as an Innovative Method to Assess Pancreases After Preservation ” (1). After analyzing the ex situ assessment of pancreases by normothermic reperfusion (NR), the authors suggested that HMPO2 may be better than SCS; they a further compared two different HMPO2 perfusates: Belzer-MPS and IGL-2. We would like to point out some considerations concerning this perfusate comparison. Speci fi cally, when the water content in pancreas grafts (as a surrogate for edema assessment) was measured in hypothermic conditions. Under those conditions, IGL2HMP pancreases showed a lower water content than the UWHMP group. These results are concomitant with the lower amylase and lipase levels, well known as injury markers for pancreas in static preservation, which has been validated recently as well in dynamic condition by Branchereau et al. This higher injury prevention exerted by IGL2 would be associated with the water content gain, which in turn is regulated by the presence of oncotic agents such as PEG35 (in