LAUSR

Molecular Assemblies Including Nucleic Acids for Functional Materials and Systems The original and fundamental function of nucleic acids is to store the genetic information required to synthesize proteins Since mRNA encodes the amino acid sequence of the protein to be expressed, it is attracting attention as biomedical material exemplified as a vaccine against SARS-CoV-2 During the fibrin gel formation by the catalytic activity of thrombin, the thrombin aptamer unit enables the internalization of bApt into fibrin gel Since another aptamer unit, which is interacting with the drug molecule, can be easily exchanged depending on the therapeutic target, the assembled fibrin gel can be a biocompatible material that stores and releases various drug molecules [7] [ ]the assembly of Puf family proteins on the 3′ untranslated region of mRNA affects protein expression Since the target RNA sequence of the Puf family proteins can be altered by rationally designing amino acids in their RNA binding domain, a strategy that assembles multiple Puf proteins on target mRNA would enable the efficient regulation of protein expression Since the strong suppression was observed only when the four types of TTP-PUF fusion proteins are present as it is like a logic gate, the technology is expected to be applied as a gene regulation tool in the field of synthetic biology