LAUSR

Simple Summary In most countries, antibiotic growth promoters are restricted or banned in the livestock industry, and probiotics have been widely explored to replace them. Lactobacillus LP184 and Yeast SC167 were selected as probiotic strains that could remain viable in feed and the gastrointestinal tract and were combined to form a compound to act as a substitute for antibiotics in broilers’ diets. This study aimed to investigate the effects of the compound probiotics as a potential alternative to antibiotics in broiler production. The feeding trial contained three dietary treatments and lasted for 42 days. The negative control group was fed the basal diet. The positive control group was fed the basal diet supplemented with commercial antibiotics. The probiotics group was fed the basal diet containing the compound probiotics. The results showed that the compound probiotics were a competent alternative for synthetic antibiotics to improve the production of broilers. The compound probiotics enhanced the immune and antioxidant capacities of broilers, which could not be achieved using antibiotics. The positive effects of the compound probiotics on the growth performance and health of broilers can likely be attributed to the improvement of intestinal morphology and cecal microbial diversity, effects which are distinct from those of antibiotics. These findings demonstrate the feasibility of replacing antibiotics with compound probiotics in broilers’ diets. Abstract The current study aimed to investigate the effects of a new probiotic compound developed as a potential alternative to synthetic antibiotics for broilers. A total of 360 newly hatched Arbor Acres male chicks were randomly divided into three treatment groups. Each treatment consisted of six replicates with 20 birds in each replicate. The negative control group was fed the basal diet. The positive control group was fed the basal diet supplemented with a commercial antimicrobial, virginiamycin, at 30 mg/kg of basal feed. The compound probiotics group was fed a basal diet containing 4.5 × 106 CFU of Lactobacillus LP184 and 2.4 × 106 CFU of Yeast SC167 per gram of basal feed. The feeding trial lasted for 42 days. The results showed that the compound probiotics were a competent alternative to synthetic antibiotics for improving the growth performance and carcass traits of broilers. The compound probiotics enhanced the immune and antioxidant capacities of the broilers, while antibiotics lacked such merits. The positive effects of compound probiotics could be attributed to an improvement in the intestinal morphology and cecal microbial diversity of broilers, effects which are distinct from those of antibiotics. These findings revealed the differences between probiotics and antibiotics in terms of improving broilers’ performance and enriched the basic knowledge surrounding the intestinal microbial structure of broilers.