LAUSR

Simple Summary Toxicologists know that peroxisome proliferator-activated receptors α agonists can induce peroxisomal proliferation in the liver of rodents but do not know whether pexophagy follows peroxisome proliferation. We showed that clofibrate, a peroxisome proliferator-activated receptors α agonist, induced pexophagy in the high-fat diet-fed rats through the pexophagy regulators. These novel findings suggested that rodent peroxisome proliferation with peroxisome proliferator-activated receptors α agonists is useful for understanding the biology of pexophagy in mammals and impacts the research on selected autophagy.