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Molybdenum Disulfide/Nickel-Metal Organic Framework Hybrid Nanosheets Based Disposable Electrochemical Sensor for Determination of 4-Aminophenol in Presence of Acetaminophen

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The toxicity of commonly used drugs, such as acetaminophen (ACAP) and its degradation-derived metabolite of 4-aminophenol (4-AP), underscores the need to achieve an effective approach in their simultaneous electrochemical determination.… Click to show full abstract

The toxicity of commonly used drugs, such as acetaminophen (ACAP) and its degradation-derived metabolite of 4-aminophenol (4-AP), underscores the need to achieve an effective approach in their simultaneous electrochemical determination. Hence, the present study attempts to introduce an ultra-sensitive disposable electrochemical 4-AP and ACAP sensor based on surface modification of a screen-printed graphite electrode (SPGE) with a combination of MoS2 nanosheets and a nickel-based metal organic framework (MoS2/Ni-MOF/SPGE sensor). A simple hydrothermal protocol was implemented to fabricate MoS2/Ni-MOF hybrid nanosheets, which was subsequently tested for properties using valid techniques including X-ray diffraction (XRD), field emission-scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDX), Fourier transformed infrared spectroscopy (FTIR), and N2 adsorption-desorption isotherm. The 4-AP detection behavior on MoS2/Ni-MOF/SPGE sensor was followed by cyclic voltammetry (CV), chronoamperometry and differential pulse voltammetry (DPV). Our experimental findings on the generated sensor confirmed a broad linear dynamic range (LDR) for 4-AP from 0.1 to 600 μM with a high sensitivity of 0.0666 μA/μM and a low limit of detection (LOD) of 0.04 μM. In addition, an analysis of real specimens such as tap water sample as well as a commercial sample (acetaminophen tablets) illuminated the successful applicability of as-developed sensor in determining ACAP and 4-AP, with an impressive recovery rate.

Keywords: organic framework; spectroscopy; metal organic; disposable electrochemical; sensor; hybrid nanosheets

Journal Title: Biosensors
Year Published: 2023

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