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Oncolytic Adenoviruses: Strategies for Improved Targeting and Specificity

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Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene… Click to show full abstract

Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.

Keywords: improved targeting; adenoviruses strategies; specificity oncolytic; oncolytic adenoviruses; strategies improved; specificity

Journal Title: Cancers
Year Published: 2020

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