LAUSR

Simple Summary Despite numerous benefits of cone-beam computed tomography (CBCT), its applications to radiotherapy were limited mainly due to degraded image quality. Recently, enhancing the CBCT image quality by generating synthetic CT image by deep convolutional neural network (CNN) has become frequent. Most of the previous works, however, generated synthetic CT with simple, classical intensity-driven loss in network training, while not specifying a full-package of verifications. This work trained the network by combining feature- and intensity-driven losses and attempted to demonstrate clinical relevance of the synthetic CT images by assessing both image similarity and dose calculating accuracy throughout a commercial Monte-Carlo. Abstract Deep convolutional neural network (CNN) helped enhance image quality of cone-beam computed tomography (CBCT) by generating synthetic CT. Most of the previous works, however, trained network by intensity-based loss functions, possibly undermining to promote image feature similarity. The verifications were not sufficient to demonstrate clinical applicability, either. This work investigated the effect of variable loss functions combining feature- and intensity-driven losses in synthetic CT generation, followed by strengthening the verification of generated images in both image similarity and dosimetry accuracy. The proposed strategy highlighted the feature-driven quantification in (1) training the network by perceptual loss, besides L1 and structural similarity (SSIM) losses regarding anatomical similarity, and (2) evaluating image similarity by feature mapping ratio (FMR), besides conventional metrics. In addition, the synthetic CT images were assessed in terms of dose calculating accuracy by a commercial Monte-Carlo algorithm. The network was trained with 50 paired CBCT-CT scans acquired at the same CT simulator and treatment unit to constrain environmental factors any other than loss functions. For 10 independent cases, incorporating perceptual loss into L1 and SSIM losses outperformed the other combinations, which enhanced FMR of image similarity by 10%, and the dose calculating accuracy by 1–2% of gamma passing rate in 1%/1mm criterion.