LAUSR

Simple Summary By integrating large-scale transcriptomic and genomic data, this study identified immune-related pathways with aging characteristics among 25 cancer types. We found that the perturbation of immune-related pathways showed a cancer-specific expression pattern. Moreover, the aging- and cancer-related dysregulated patterns of pathways were in the same direction in most cancer types. Furthermore, the study found that aging-related immune pathways with clinical relevance improved immunotherapy benefits in melanoma and non-small cell lung cancer patients. Using a network-based method, this study predicted potential drug targets for immunotherapy and treatment combinations. Collectively, this study may provide insight into cancer immunotherapy, thus improving treatment benefits. Abstract (1) Background: Perturbation of immune-related pathways can make substantial contributions to cancer. However, whether and how the aging process affects immune-related pathways during tumorigenesis remains largely unexplored. (2) Methods: Here, we comprehensively investigated the immune-related genes and pathways among 25 cancer types using genomic and transcriptomic data. (3) Results: We identified several pathways that showed aging-related characteristics in various cancers, further validated by conventional aging-related gene sets. Genomic analysis revealed high mutation burdens in cytokines and cytokines receptors pathways, which were strongly correlated with aging in diverse cancers. Moreover, immune-related pathways were found to be favorable prognostic factors in melanoma. Furthermore, the expression level of these pathways had close associations with patient response to immune checkpoint blockade therapy in melanoma and non-small cell lung cancer. Applying a net-work-based method, we predicted immune- and aging-related genes in pan-cancer and utilized these genes for potential immunotherapy drug discovery. Mapping drug target data to our top-ranked genes identified potential drug targets, FYN, JUN, and SRC. (4) Conclusions: Taken together, our systematic study helped interpret the associations among immune-related pathways, aging, and cancer and could serve as a resource for promoting clinical treatment.