LAUSR

Simple Summary Although survival after rhabdosarcoma treatment has improved over the years, one third of patients still develop locoregional relapse. This review aims to highlight developments pertaining to staging and local treatment of specific RMS tumor sites, including head and neck, chest/trunk, bladder-prostate, female genito-urinary, perianal, and extremity sites. It also aims to address the local treatment strategies of subgroups of patients who are very young, or those with metastatic or relapsed disease. Specific surgical techniques like whole limb perfusion, HIPEC and fluorescence guided surgery are discussed separately. The goal of the innovations is improving loco-regional control of disease, whilst minimizing morbidity of treatment strategies. Abstract Although survival after rhabdosarcoma treatment has improved over the years, one third of patients still develop locoregional relapse. This review aims to highlight developments pertaining to staging and local treatment of specific RMS tumor sites, including head and neck, chest/trunk, bladder-prostate, female genito-urinary, perianal, and extremity sites.