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An organic catalyst “(R, R)-1,2-diphenylethylenediamine(DPEN) derivative’’ was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted… Click to show full abstract
An organic catalyst “(R, R)-1,2-diphenylethylenediamine(DPEN) derivative’’ was devel-oped as a chiral bifunctional organocatalyst and applied for asymmetric Michael additions of aromatic ketones to trans-β-nitroalkene compounds under neutral conditions. The isopropyl-subs-tituted thiourea catalyst in neutral condition provides high chemical yield and enantioselectivities (ee) (up to 96% yield, 98% ee).
Keywords:
ketones unsaturated;
michael;
organocatalytic asymmetric;
michael addition;
asymmetric michael;
addition ketones
Journal Title: Catalysts
Year Published: 2020
Link to full text (if available)
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Journal Title: Catalysts
Year Published: 2020
Link to full text (if available)
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recommendations!