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The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other… Click to show full abstract
The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other steroids, and it is implicated in prostate cancer. The obtained compounds are potent enzyme inhibitors (sub µM) with antiproliferative activity in prostate cancer cell lines. The binding mode of these compounds is also discussed.
Keywords:
cancer;
p450 17a1;
cytochrome p450;
prostate cancer
Journal Title: International Journal of Molecular Sciences
Year Published: 2020
Link to full text (if available)
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Journal Title: International Journal of Molecular Sciences
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!