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FDA-Approved Fluorinated Heterocyclic Drugs from 2016 to 2022

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The inclusion of fluorine atoms or heterocyclic moiety into drug structures represents a recurrent motif in medicinal chemistry. The combination of these two features is constantly appearing in new molecular… Click to show full abstract

The inclusion of fluorine atoms or heterocyclic moiety into drug structures represents a recurrent motif in medicinal chemistry. The combination of these two features is constantly appearing in new molecular entities with various biological activities. This is demonstrated by the increasing number of newly synthesized fluorinated heterocyclic compounds among the Food and Drug Administration FDA-approved drugs. In this review, the biological activity, as well as the synthetic aspects, of 33 recently FDA-approved fluorinated heterocyclic drugs from 2016 to 2022 are highlighted.

Keywords: fluorinated heterocyclic; drugs 2016; approved fluorinated; 2016 2022; fda approved; heterocyclic drugs

Journal Title: International Journal of Molecular Sciences
Year Published: 2023

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