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Cyclic Imines and Their Salts as Universal Precursors in the Synthesis of Nitrogen-Containing Alkaloids

Alkaloids are predominantly nitrogen-containing heterocyclic compounds that are usually isolated from plants, and sometimes from insects or animals. Alkaloids are one of the most important types of natural products due… Click to show full abstract

Alkaloids are predominantly nitrogen-containing heterocyclic compounds that are usually isolated from plants, and sometimes from insects or animals. Alkaloids are one of the most important types of natural products due to their diverse biological activities and potential applications in modern medicine. Cyclic imines were chosen as starting compounds for the synthesis of alkaloids due to their high synthetic potential. Thus, this review summarizes the achievements in the synthesis of various alkaloids from cyclic imines, paying special attention to stereoselective methods used for their preparation. Information on the biological activity of some alkaloids, their application and occurrence in natural objects is presented. Synthesis methods are classified based on the type of alkaloid obtained.

Keywords: salts universal; alkaloids cyclic; nitrogen containing; cyclic imines; imines salts; universal precursors

Journal Title: International Journal of Molecular Sciences
Year Published: 2024

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