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Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin

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The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A… Click to show full abstract

The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

Keywords: highly methylated; carmabin dragomabin; total synthesis; methylated peptides; synthesis highly; synthesis

Journal Title: Marine Drugs
Year Published: 2018

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