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(−)-cis-α-Ambrinol is a natural product present in ambergris, a substance of marine origin that has been highly valued by perfumers. In this paper, we present a new approach to its… Click to show full abstract
(−)-cis-α-Ambrinol is a natural product present in ambergris, a substance of marine origin that has been highly valued by perfumers. In this paper, we present a new approach to its total synthesis. The starting material is commercially available α-ionone and the key step is an intramolecular Barbier-type cyclization induced by CpTiCl2, an organometallic compound prepared in situ by a CpTiCl3 reduction with Mn.
Keywords:
synthesis;
synthesis ambrinol;
total synthesis;
diastereoselective total;
concise diastereoselective
Journal Title: Marine Drugs
Year Published: 2023
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Journal Title: Marine Drugs
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!