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The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. “Inflame-ageing” and “immune-senescence” are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and… Click to show full abstract
The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. “Inflame-ageing” and “immune-senescence” are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials.
Keywords:
frail;
vaccine effectiveness;
elderly frail;
covid mrna;
mrna vaccine;
effectiveness elderly
Journal Title: Medicina
Year Published: 2023
Link to full text (if available)
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Journal Title: Medicina
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!