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Stereocontrolled synthesis of some amino acid-based carbocyclic nucleoside analogs containing ring C=C bond has been performed on β- and γ-lactam basis. Key steps were N-arylation of readily available β- or… Click to show full abstract
Stereocontrolled synthesis of some amino acid-based carbocyclic nucleoside analogs containing ring C=C bond has been performed on β- and γ-lactam basis. Key steps were N-arylation of readily available β- or γ-lactam-derived amino ester isomers and amino alcohols with 5-amino-4,6-dichloropyrimidine; ring closure of the formed adduct with HC(OMe)3 and nucleophilic displacement of chlorine with various N-nucleophiles in the resulting 6-chloropurine moiety.
Keywords:
based carbocyclic;
acid based;
amino acid;
nucleoside analogs;
carbocyclic nucleoside
Journal Title: Molecules
Year Published: 2019
Link to full text (if available)
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Journal Title: Molecules
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!