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We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a… Click to show full abstract
We report herein an efficient synthesis of furopyran derivatives through a gold(I)-catalyzed domino reaction. The cascade reaction starts with two regioselective cyclizations, a 5-endo-dig and a 8-endo-dig, followed with a Grob-type fragmentation and a hetero Diels–Alder. The obtained furopyran derivatives contain fused and spiro-heterocycles. During this one-pot process, four bonds and four controlled stereogenic centers including a quaternary center are formed.
Keywords:
domino reaction;
reaction;
catalyzed domino;
reaction furopyrans;
gold catalyzed
Journal Title: Molecules
Year Published: 2020
Link to full text (if available)
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Journal Title: Molecules
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!