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Amide-Assisted Rearrangement of Hydroxyarylformimidoyl Chloride to Diarylurea

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A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained… Click to show full abstract

A novel amide-assisted rearrangement reaction of hydroxybenzimidoyl chloride has been established for the efficient synthesis of 1,3-diphenylurea derivatives. A variety of electronically and sterically different 1,3-diphenylurea derivatives can be obtained in good to excellent yields, and a proposed reaction mechanism is also presented.

Keywords: assisted rearrangement; chloride diarylurea; rearrangement hydroxyarylformimidoyl; hydroxyarylformimidoyl chloride; amide assisted

Journal Title: Molecules
Year Published: 2021

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