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A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc… Click to show full abstract
A convenient procedure of synthesis of N-carbamoyl-protected propargylic amines substituted with a cyclopropyl group from α-amido sulfones and cyclopropylacetylene is described. The reaction is catalyzed by a chiral BINOL-type zinc complex and provides the corresponding products in good yields and enantioselectivities.
Keywords:
cyclopropylalkynylation aldimines;
catalytic enantioselective;
generated situ;
amido sulfones;
aldimines generated;
enantioselective cyclopropylalkynylation
Journal Title: Molecules
Year Published: 2022
Link to full text (if available)
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Journal Title: Molecules
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!