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Boron Trifluoride Etherate Promoted Regioselective 3-Acylation of Indoles with Anhydrides

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An efficient, high-yielding and scalable procedure for the regioselective 3-acylation of indoles with anhydrides promoted by boron trifluoride etherate under mild conditions was reported. This novel protocol provided a simple… Click to show full abstract

An efficient, high-yielding and scalable procedure for the regioselective 3-acylation of indoles with anhydrides promoted by boron trifluoride etherate under mild conditions was reported. This novel protocol provided a simple way to prepare 3-(benzofuran-2-yl) indole in three steps.

Keywords: boron trifluoride; regioselective acylation; trifluoride etherate; acylation indoles; indoles anhydrides

Journal Title: Molecules
Year Published: 2022

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