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A simple and concise three-component synthesis of a key pyrrole framework was developed from the reaction between α-hydroxyketones, oxoacetonitriles, and anilines. The synthesis was used to obtain several pyrrole-based drug… Click to show full abstract
A simple and concise three-component synthesis of a key pyrrole framework was developed from the reaction between α-hydroxyketones, oxoacetonitriles, and anilines. The synthesis was used to obtain several pyrrole-based drug candidates, including COX-2 selective NSAID, antituberculosis lead candidates BM212, BM521, and BM533, as well as several analogues. This route has potential to obtain diverse libraries of these pyrrole candidates in a concise manner to develop optimum lead compounds.
Keywords:
based drug;
drug candidates;
synthesis;
pyrrole based
Journal Title: Molecules
Year Published: 2023
Link to full text (if available)
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Journal Title: Molecules
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!