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Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones

In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical… Click to show full abstract

In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS analysis and cyclic voltammetry study, a plausible mechanism for this selenylation was proposed.

Keywords: selenylation; selenylation pyrido; pyrido pyrimidin; pyrimidin ones

Journal Title: Molecules
Year Published: 2023

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