Photo by omarprestwich from unsplash
A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the… Click to show full abstract
A novel, low-cost method for the preparation of not easily accessible free 3-aminoindoles has been developed. This approach is based on a well-established reaction between indoles and nitrostyrene in the presence of phosphorous acid, which results in the formation of 4′-phenyl-4′H-spiro[indole-3,5′-isoxazoles]. The latter could be transformed to corresponding aminated indoles by reaction with hydrazine hydrate in good or excellent yields upon microwave-assisted heating.
Keywords:
synthesis unprotected;
two step;
unprotected aminoindoles;
via post;
step synthesis;
aminoindoles via
Journal Title: Molecules
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Molecules
Year Published: 2023
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!