LAUSR

To date, both in monkeys and humans, very few studies have addressed the issue of the lateralization of the cortical parietal and premotor areas involved in the organization of voluntary movements and in-action understanding. In this review, we will first analyze studies in the monkey, describing the functional properties of neurons of the parieto-frontal circuits, involved in the organization of reaching-grasping actions, in terms of unilateral or bilateral control. We will concentrate, in particular, on the properties of the mirror neuron system (MNS). Then, we will consider the evidence about the mirror neuron mechanism in humans, describing studies in which action perception, as well as action execution, produces unilateral or bilateral brain activation. Finally, we will report some investigations demonstrating plastic changes of the MNS following specific unilateral brain damage, discussing how this plasticity can be related to the rehabilitation outcome