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This Special Issue contains 14 articles from the MDPI journal Symmetry on the general subject area of “Special Functions and Polynomials”, written by scholars belonging to different countries of the world. A similar number of submitted articles was not accepted for publication. Several successful Special Issues on the same or closely related topics have already appeared in MDPI’s Symmetry, Mathematics and Axioms journals, in particular those edited by illustrious colleagues such as Hari Mohan Srivastava, Charles F. Dunkl, Junesang Choi, Taekyun Kim, Gradimir Milovanović, and many others, who testify to the importance of this matter for its applications in every field of mathematical, physical, chemical, engineering and statistical sciences. The subjects treated in this Special Issue include, in particular, the following Keywords.