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Botulinum Neurotoxin Injections in Children with Self-Injurious Behaviors

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Self-injurious behaviors are repetitive, persistent actions directed toward one’s body that threaten or cause physical harm. These behaviors are seen within a broad spectrum of neurodevelopmental and neuropsychiatric conditions, often… Click to show full abstract

Self-injurious behaviors are repetitive, persistent actions directed toward one’s body that threaten or cause physical harm. These behaviors are seen within a broad spectrum of neurodevelopmental and neuropsychiatric conditions, often associated with intellectual disability. Injuries can be severe and distressing to patients and caregivers. Furthermore, injuries can be life-threatening. Often, these behaviors are challenging to treat and require a tiered, multimodal approach which may include mechanical/physical restraints, behavioral therapy, pharmacotherapy, or in some cases, surgical management, such as tooth extraction or deep brain stimulation. Here, we describe a series of 17 children who presented to our institution with self-injurious behaviors in whom botulinum neurotoxin injections were found helpful in preventing or lessening self-injury.

Keywords: injurious behaviors; self injurious; injections children; botulinum neurotoxin; neurotoxin injections; behaviors botulinum

Journal Title: Toxins
Year Published: 2023

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