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The predictive value of KRAS and NRAS mutations in metastatic colorectal cancer

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1. Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran 2. Qom Islamic Azad University, Qom, Iran ↑What is “already known” in this topic: The RAS oncogene family is… Click to show full abstract

1. Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran 2. Qom Islamic Azad University, Qom, Iran ↑What is “already known” in this topic: The RAS oncogene family is widely accepted and is the most studied gene among cancer related genes. Approximately, 17%-25% of the CRC patients present KRAS mutation. KRAS mutation results in the poorer survival and response to the antiEGFR therapies.

Keywords: mutations metastatic; kras nras; value kras; nras mutations; cancer; predictive value

Journal Title: Medical Journal of the Islamic Republic of Iran
Year Published: 2020

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