LAUSR

To explore the efficacy and safety of endoscopic resection and open surgery for treating thyroid diseases using meta-analysis. Related data in computer retrieval of Cochrane Library, American National Library of Medicine Biomedical Information Retrieval System (Pub Med), Dutch Medicine Abstracts (Embase), China Biomedical Literature Database (CBM), China Academic Journals Full-text Database (CNKI), Chinese Science and Technology Journal Database (VIP), and Western Language Biomedical Journal Literature Database (EMC) from December 2019 to April 2020 were retrieved. Relevant journals and included references were manually searched. Randomized controlled trials regarding the effects of endoscopic thyroid surgery and open thyroid surgery on the immune response of thyroid diseases were included. Two reviewers conducted independent data extraction, quality evaluation and cross-checking according to inclusion and exclusion criteria. RevMan 5.1.4 software was employed. Eight non-randomized controlled retrospective cohort studies were finally included. The curative rate (168/185, 90.81 % vs. 194/383, 50.65 %, p<0.01) was significantly higher in endoscopic resection group and the difference between local recurrence rates (2/366, 0.55 % vs. 83/603, 13.76 %, p<0.01) was significant. There was no significant difference between bleeding rate (1/325, 0.31 % vs. 4/407, 0.98 %, p=0.41). In terms of performing thyroid surgery under endoscopy, the efficacy of adjuvant treatment under endoscopy is significantly better than that of control group and the safety is similar to that of control group. Endoscopic treatment is suitable for treating thyroid diseases. However, the conclusions still need to be verified by multicenter randomized controlled trials with large sample sizes.