LAUSR

OBJECTIVE The aim: To investigate the prevalence of antibiotic-resistant strains from the association of E. coli - E. faecalis in the urogenital tract of pregnant women. PATIENTS AND METHODS Materials and methods: Used bacteriological method of sectoral culture of urine on nutrient media and identification of strains to the species. The susceptibility of strains to antibiotics was determined by disk-diffusion method, the interpretation of results - according to current EUCAST recommendations. Statistical processing was performed in MS Excel (Analysis of variance (ANOVA)). RESULTS Results: The number of resistant to cefuroxime, cephalexin, nitrofurantoin, norfloxacin and trimethoprim uropathogenic strains of Escherichia coli does not change depending on the monostrain and associated strain of E. coli from the urine of pregnant women in Dnipro. It was found that the differences in the number of fosfomycin-resistant uropathogenic strains of E. coli depending on the type of culture - the number of fosfomycintolerant urostrains E. coli is 2 times higher among the associated strains, compared with monostains of the studied microorganism. The number of uropathogenic strains of E. faecalis resistant to ampicillin, trimethoprim, nitrofurantoin and norfloxacin does not change depending on the type of culture isolated from the urine of pregnant women in Dnipro. CONCLUSION Conclusions: The symbiotic type of existence of two representatives of the normal intestinal flora on the uroepithelium of pregnant women may be associated with the development of Escherichia coli antibiotic resistance only to fosfomycin compared with monoinfection caused by each of these microorganisms.