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OBJECTIVE The aim: The aim of investigation was to determine the effect of the proposed treatment of patients with generalized periodontitis and psychoemotional stress on changes in the immune system of patients. PATIENTS AND METHODS Materials and methods: The clinical and laboratory investigations were conducted to revealed the effectiveness of the proposal complex of adrenoblockers in complex treatment of generalized periodontitis in 40 patients with psychoemotional stress. To assess the effectiveness of the treatment, the level of cortisol in saliva was determined. 40 patients with chronic course of generalized periodontitis I-II grade were divided into two subgroups: main and control. For the treatment of main subgroup patients used a modified enhanced complex of adrenoblockers to suppress the manifestations of psychoemotional stress. RESULTS Results: The effectiveness of usage of the proposed complex of adrenoblockers were revealed after treatment of main group patients. The complex of adrenoblockers lead to stabilization of the generalized periodontitis in patients with psychoemotional stress. Such combination of adrenoblockers oppresses main symptoms of psychoemotional stress in with generalized periodontitis as evidenced by the decrease of cortisol levels in the patients saliva. CONCLUSION Conclusions: As a result of researches the obtained data testify to achievement of stabilization of pathological process in a periodontium. All this together demonstrates the beneficial effect of the proposed complex of adrenoblockers on the dystrophic-inflammatory process in the periodontium. Decreased levels of cortisol in saliva indicate a decrease in the manifestations of psychoemotional stress in patients with generalized periodontitis.