LAUSR

Chlorothalonil (CTL) is a broad spectrum, non-systemic, organo-chlorine fungicide, widely used in agriculture, silviculture, urban settings, and industrial antifouling. It is found in various environmental media, such as surface water, soil, and air, and even ex-ceeded Maximum residual limit (MRL) in food chain [1,2]. Previous studies revealed that CTL is highly toxic to aquatic organisms and amphibian, especially in the early stage of development [3]. Under experimental conditions, it may also have toxic effects on rodents, mammalian cells, and other non target organisms. In humans, the main exposure modes of CTL were contacting to the residues in the work/life place or intaking the contaminated dietary, which may cause contact allergic dermatitis, occupational asthma, gastro-intestinal problems and other symptoms [4]. However, the effects of CTL on the “liver-gut axis” have not been reported yet. In this study, after one week of adaptation to the environment, six-week-old male ICR mice (China