LAUSR

OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover that OLFM4 expression is significantly reduced in metastatic cervical cancer. Accordingly, overexpression of OLFM4 inhibits epithelial-mesenchymal transition (EMT), migration and invasion in human cervical cancer cells. To further explore the molecular mechanisms of it, we reveal that OLFM4 augmentation interferes with mTOR signal pathway and the suppressive effects of OLFM4 on cell migration and invasion are largely weakened by phosphatidic acid (PA) induced mTOR signal activation, which implicates the potential role of mTOR pathway in OLFM4-related cervical metastasis. In conclusion, our results confirm OLFM4 as a tumor suppressor that inhibits cervical cancer metastasis by regulating mTOR signal pathway.