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2-Substituted Benzimidazole Synthesis in Dry Medium Mediated by Pyridine N-oxide

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Substituted benzimidazoles were obtained from o-phenylenediamine and organic halides in solvent-free medium. The procedure involves pyridine N-oxide as mild oxidizing agent. The benzimidazoles were prepared without the separation of the… Click to show full abstract

Substituted benzimidazoles were obtained from o-phenylenediamine and organic halides in solvent-free medium. The procedure involves pyridine N-oxide as mild oxidizing agent. The benzimidazoles were prepared without the separation of the intermediates. The absence of catalysts and good yields are important benefits of the method.

Keywords: pyridine oxide; substituted benzimidazole; medium; dry medium; benzimidazole synthesis; synthesis dry

Journal Title: Revista de Chimie
Year Published: 2019

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