LAUSR

Placentas from gestational diabetes mellitus (GDM) are Patterns of fetoplacental angiogenesis of GDM oftenhypervascularized. Placenta is a mirror that reflects the well-being of the fetus and continuously undergoesa change in weight, structure, shape and function in order to support the well-being of the fetus.Aim of Study: In this work we attempted to identify villous vascular and morphological changes in a groupof term placentae from mothers with GDM complicating pregnancy.Objective: To analysis on the possible gross morphological changes and Patterns of fetoplacentalangiogenesis of GDM.Materials and Method: The study was observational, analytical and cross sectional. The patients under thisstudy were selected from the Obstetric of AL-Emam AL-sadiq in the Babylon province. A total of eightysamples were collected from women completed weeks of gestation. Among them, 40 samples were frommothers having GDM, 40 belonged to normal pregnancy (control group). The placentas were examinedto measure their weight, diameter, thickness, cotyledons number, Insertion of umbilical cord, Vascularpattern and Fasting blood glucose were determined by enzymatic method using Envoy® 500 reagents .Betachorionic gonadotrophin, progesterone and estradiol were determined using chemilumiscence immunoassaytechnique on MAGLUMI 600 analyzer.Results: In this study, the GDM group showed significantly higher values for the variables of the weight,thickness,diameter, number of cotyledons, Patterns of fetoplacental angiogenesis of GDM and placentashypervascularized as compared to normal group. Consequences of GDM include increased risk of macrosomiaand birth complications in the infant. Fasting plasma glucose FBG, ?-HCG, P4, E2 were increased in thegestational diabetic women.Conclusion: From the findings of this study, placental variations in diabetic and normal mothers duringpregnancy. The variations in placental weight, thickness, diameter and fetoplacental angiogenesis foundin gestational diabetic mother may be a long term compensatory mechanism, aiming to secure a sufficientnutrient supply to support the growth of the foetus. So, postnatal examination of the placenta can yieldinformation that may be important for immediate and late management of the mother and neonate. Fastingplasma glucose FBG, ?-HCG, P4, E2 were increased in GDM group was aimed at assessing placentalpeptides and maternal factors as potential predictors of the development of gestational diabetes amongpregnant women. GDM appears to effect the microvascular remodeling at angiogenesis. So gestationaldiabetes mellitus (GDM) need to be identified early in pregnancy and managed to maintain a normalvasculature and prevent neonatal mortality and morbidity if rapid intervention is completed.