LAUSR

Objective To evaluate the efficacy and safety of tolterodine in children with bladder spasm after cystostomy. Methods A total of 60 children between 5 and 12 years old operated by cystostomy were enrolled. Thirty-two children received tolterodine (trail group, 2 mg twice daily), 28 children received propantheline bromide [control group, 2 mg·(kg·d)-1, twice daily]. Drugs were dispensed to children firstly 6 hours later after operations. The frequency and degree of bladder spasm in different periods of each child after cystostomy were recorded. Spasm pain was assessed using Visual Analog Scale (VAS, 0=no pain, 10=pain as bad as it cloud possibly be). Results The frequency of bladder spasm in tolterodine group (T group) was no different with that in propantheline bromide (P group) during t1 (operation-6 h after operation) (P>0.05). The bladder spasm episodes in T group during t2, t3 and t4 (6~48 h after operation) were significantly lower than those in P group (P 0.05). The incidence of side effects such as dry mouth, flushing and constipation were significantly lower in T group than those in P group. Conclusions Tolterodine can effectively reduce the number of bladder spasm attack and relieve the pain symptom after cystostomy. It also has a lower incidence of side effects such as dry mouth, flushing and constipation. Tolterodine may be safety and effective to bladder spasm in children. Key words: Cystostomy; Spasm; Postoperative Complications