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In this study, six-membered N-acyliminium ions were generated by the “indirect cation pool” method and reacted with several nucleophiles. These reactions afforded disubstituted piperidine derivatives with high diastereoselectivities and good… Click to show full abstract
In this study, six-membered N-acyliminium ions were generated by the “indirect cation pool” method and reacted with several nucleophiles. These reactions afforded disubstituted piperidine derivatives with high diastereoselectivities and good to excellent yields. The conformations of the obtained N-acyliminium ions were studied by low temperature NMR analyses and DFT calculations and were found to be consistent with the Steven’s hypothesis.
Keywords:
indirect cation;
cation pool;
acyliminium ions;
dft calculations;
pool method
Journal Title: Beilstein Journal of Organic Chemistry
Year Published: 2018
Link to full text (if available)
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Journal Title: Beilstein Journal of Organic Chemistry
Year Published: 2018
Link to full text (if available)
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recommendations!