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A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)2-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles. These findings are in contrast to the previously reported base-promoted… Click to show full abstract
A three-component reaction involving in situ generation of propargylureas and subsequent Zn(OTf)2-mediated cyclocondensation with a primary amine yielded trisubstituted 2-aminoimidazoles. These findings are in contrast to the previously reported base-promoted unimolecular cyclization of propargylureas (leading to 2-imidazolones) and extend the range of Lewis acid-catalyzed azole syntheses based on N-carbonyl propargylamines.
Keywords:
otf mediated;
trisubstituted aminoimidazoles;
component otf;
three component;
mediated entry;
entry trisubstituted
Journal Title: Beilstein Journal of Organic Chemistry
Year Published: 2019
Link to full text (if available)
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Journal Title: Beilstein Journal of Organic Chemistry
Year Published: 2019
Link to full text (if available)
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recommendations!