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The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. Here, we report a mild, efficient, functional group tolerant, and highly chemoselective N-acylation of indoles using thioesters… Click to show full abstract
The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. Here, we report a mild, efficient, functional group tolerant, and highly chemoselective N-acylation of indoles using thioesters as a stable acyl source. A series of indoleamides have been obtained with moderate to good yields. In addition, heterocycles, such as carbazole, can also be used as nucleophiles in this reaction.
Keywords:
using thioesters;
acyl source;
indoles using;
acylation indoles;
chemoselective acylation;
acylation
Journal Title: Beilstein Journal of Organic Chemistry
Year Published: 2022
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Journal Title: Beilstein Journal of Organic Chemistry
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!