LAUSR

https://ejgo.org In March, the results of the Laparoscopic Approach to Carcinoma of the Cervix (LACC) trial were announced at the 2018 Society of Gynecologic Oncology (SGO) annual meeting, bringing in a significant wave. Minimally invasive surgery has been shown to have better surgical outcomes with equivalent survival rates in patients with endometrial, colorectal, and gastric cancer in previous randomized controlled trials [1-4]. It was expected that the same result would be obtained in cervical cancer, but the disease-free survival and overall survival rate of minimally invasive radical hysterectomy (MIS RH) surgery group was significantly lower than that of open radical hysterectomy (ORH) surgery in LACC trial. In the retrospective analysis using National Cancer Institute (NCI)'s Surveillance, Epidemiology, and End Results (SEER) data in the US, the introduction of MIS was associated with an increase in the mortality rate due to cervical cancer, thus further strengthening the results of the LACC trial. These results have already been published outside the medical community, will affect the practice of gynecologic oncologists, and are likely to change the treatment guideline of cervical cancer. However, before accepting the results of the LACC trial, we must go through a lot of important things that were not considered and controlled, and thus biased the results in the LACC trial and the analysis using NCI's SEER data in the US.