LAUSR

The aim of the present study was to investigate the function of the DNA topoisomerase IIα (TOP2A) gene and its associated genes in the progression of papillary renal cell carcinoma (PRCC). Online cancer databases, including cBioportal, Oncomine, OncoLnc and Search Tool for the Retrieval of Interacting Genes/Proteins were used to analyze the TOP2A gene expression profile, function and regulation network in PRCC. The genes that were significantly co-expressed or mutually exclusively expressed with TOP2A were identified. The genes co-expressed with TOP2A were defined as a 'TOP2A-cancer panel', which cooperatively promotes PRCC progression. This gene panel performed well in predicting the prognosis of PRCC. In addition, the TOP2A-cancer panel significantly affected the outcome of PRCC compared with clear cell renal cell carcinoma (CCRCC). The protein-protein interaction network of all genes associated with TOP2A was also generated. This interaction network may provide foundation for the additional investigation of TOP2A. Integrative understating of the TOP2A-cancer panel may result in a novel avenue for treatment intervention in PRCC.